| Pair Name | Brusatol, Cytarabine | ||
| Phytochemical Name | Brusatol (PubChem CID: 73432 ) | ||
| Anticancer drug Name | Cytarabine (PubChem CID: 6253 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Brusatol, Cytarabine | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Gene Regulation | Down-regulation | Expression | NFE2L2 | hsa4780 |
| Down-regulation | Expression | G6PD | hsa2539 | |
| In Vitro Model | HL-60 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_0002 |
| THP-1 | Childhood acute monocytic leukemia | Homo sapiens (Human) | CVCL_0006 | |
| Result | Inhibition of Nrf2-mediated glucose metabolism by brusatol synergistically sensitizes acute myeloid leukemia to Ara-C | |||
| No. | Title | Href |
|---|---|---|
| 1 | Inhibition of Nrf2-mediated glucose metabolism by brusatol synergistically sensitizes acute myeloid leukemia to Ara-C. Biomed Pharmacother. 2021 Oct;142:111652. doi: 10.1016/j.biopha.2021.111652. | Click |
